Synthesis of insulin (تخليق الانسولين )
Synthesis of insulin (تخليق الانسولين ):
a.Preproinsulin, consisting of A &B chains joined by a C-peptide, is synthesized on the rough endoplasmic reticulum and the pre **signal** sequence is removed to form pro insulin.
b.In secretory granules, proinsulin is cleaved, and the C-peptide is released. The remainder of molecule form the active hormone.
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